Peeling skin syndrome (PSS) is a
rare recessively inherited ichthyosiform genodermatoses characterized
clinically by asymptomatic, localized or generalized, continuous exfoliation of
the superficial layer of the skin. A 12-year-old male child was presented with
history of asymptomatic peeling of skin from his
neck, trunk, and proximal extremities, since the age of 6 years. Histologically,
stratum corneum was separated from the underlying stratum granulosum. Clinical
and histopathological picture corresponded to the non-inflammatory variant of
peeling skin syndrome (type A). Biophysical profile, which includes skin
hydration, transepidermal water loss, sebum content, skin pH, of this patient
was assessed from 7 different sites using the Corneometer, Tewameter,
Sebumeter, Skin-pH-meter. Derangement was observed in all the above parameters.
Peeling skin syndrome serves as a model for studying the stratum corneum
functions. This article gives a critical review of the structure and various
barrier functions of stratum corneum.
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